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Á¦ ¸ñ Niacin ¾àÁ¦ÀÇ ¾ÈÀü¼º °í·Á¿Í ¿Ã¹Ù¸¥ »ç¿ë¹ý

safety considerations with niacin therapy



niacin has beneficial effects on plasma lipoproteins and has demonstrated clinical benefits in reducing cardiovascular events and atherosclerosis progression. the side effects of niacin, however, have limited its use in general clinical practice. an understanding of cutaneous flushing based on the best available evidence should enhance patient education efforts and improve adherence. although serious hepatic toxicity from niacin administration has been reported, it is largely confined to the use of slow-release formulations given as unregulated nutritional supplements. niacin has been shown to induce insulin resistance in short-term trials, but the glycemic response in subjects with and without diabetes is usually minor. niacin can be used safely in patients with diabetes. despite a few case reports of myopathy associated with niacin-statin (3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor) combination therapy, 2 decades of clinical evidence since the introduction of statins do not support a general myopathic effect of niacin either alone or in combination with statins. rare, less well-defined side effects of niacin include blurred vision due to cystoid macular edema, nausea and vomiting, and the exacerbation of peptic ulcers. laboratory abnormalities that are usually small (¡Â10%) and clinically unimportant include increased prothrombin time, increased uric acid, and decreases in platelet count and serum phosphorus. overall, the perception of niacin side effects is often greater than the reality. as a result, a valuable medication for cardiovascular risk is underused.



 



address for reprints: john r. guyton, md, duke university medical center, box 3510, durham, north carolina 27710.



copyright © 2007 elsevier inc. all rights reserved.



 



niacin ¾àÁ¦ÀÇ ¾ÈÀü¼º °í·Á¿Í ¿Ã¹Ù¸¥ »ç¿ë¹ý



ÀÛ¼º½Ã°£ : 2007-05-31 10:39:56 | û³âÀÇ»ç webmaster@docdocdoc.co.kr





niacinÀº Ç÷Àå Áö´Ü¹é Á¶Àý ¹× °³¼± È¿°ú°¡ ÀÖÀ¸¸ç ½ÉÇ÷°üÁúȯÀÇ ¹ß»ýÀ» °¨¼Ò½ÃÅ°¸ç µ¿¸Æ°æÈ­ ÁøÇàÀ» °¨¼ÒÇÏ´Â À̷οî È¿°ú°¡ ÀÖ´Ù.



±×·¯³ª ¾àÁ¦ È¿´ÉÀÌ ¼Ò°³µÈ Áö 50¿©³âÀÌ Áö³µÁö¸¸, ¾àÁ¦ÀÇ ºÎÀÛ¿ëÀ¸·Î ÀÎÇÏ¿© ¾àÁ¦»ç¿ë¿¡ Á¦ÇÑÀÌ ÀÖ´Â °ÍÀÌ Çö½ÇÀÌ´Ù. ºÎÀÛ¿ë Áß ÇǺΠȫÁ¶ÀÇ ¿Ã¹Ù¸¥ ÀÌÇش ȯÀÚ ±³À°À¸·Î Ä¡·á ¼øÀÀµµ¸¦ °³¼± ÇÒ ¼ö ÀÖ´Ù.



µå¹°°Ô ½É°¢ÇÑ °£µ¶¼ºÀÇ º¸°í »ç·Ê°¡ ÀÖÁö¸¸, ÀÌ´Â ±ÔÁ¦µÇÁö ¾Ê´Â ¼­¹æÇüÁ¦ÀçÀÎ °Ç°­ º¸Á¶½ÄÇ° ÇüÅ¿¡ ±¹ÇѵȴÙ.



niacinÀº ´Ü±â°£¿¡¼­´Â Àν¶¸° ÀúÇ×¼ºÀ» À¯¹ß½ÃÅ°Áö¸¸, ´ç´¢À¯¹«¿¡ °ü°è¾øÀÌ È¯ÀÚÀÇ Ç÷´ç¿¡ ´ëÇÑ ¹ÝÀÀÀº ºñ±³Àû ½É°¢ÇÏÁö ¾ÊÀ¸¸ç, ´ç´¢È¯ÀÚ¿¡¼­µµ ¾ÈÀüÇÏ°Ô »ç¿ëµÈ´Ù.



niacin ´Üµ¶ ¶Ç´Â statin º´¿ëÅõ¿© ½Ã ±ÙÀ°º´Áõ ¹ßº´ÀÇ ºÎÀÛ¿ëµµ ¸¹ÀÌ º¸°íµÇÁö´Â ¾Ê¾Ò´Ù. µå¹°°Ô ³¶Á¾ÀÇ È²¹Ý ºÎÁ¾¿¡ ÀÇÇÑ ½Ã·ÂÀúÇÏ, ¿À½É, ±¸Åä ±×¸®°í À§±Ë¾ç ¾ÇÈ­ µîÀÇ »ç·Ê´Â ÀÖ´Ù.



Àü¹ÝÀûÀ¸·Î niacin ºÎÀÛ¿ëÀº Çö½Çº¸´Ù °úÀåµÇ°Ô »ý°¢À» ÇÏ´Â °æÇâÀÌ ÀÖÀ¸¹Ç·Î, ½ÉÇ÷°üÁúȯ¿¡ °¡Ä¡ ÀÖ´Â ¾àÁ¦°¡ Àû°Ô »ç¿ëµÇ´Â °æÇâÀÌ ÀÖ´Ù.



¿©±â¿¡¼­´Â ÃÖ±Ù ¹Ì±¹ national lipid association¡¯s safety task force (the american journal of cardiology 2007:99s22-s31)¸¦ Á¤¸® ¿ä¾àÇÏ¿© niacin À¯È¿¼º°ú ¾ÈÀü¼ºÀÇ ¿Ã¹Ù¸¥ ÀÌÇØ·Î ÀÓ»óÁø·á ½Ã ¾àÁ¦ ¼±ÅÃÀÇ µµ¿òÀÌ µÇ°íÀÚ ÇÑ´Ù.



niacin À¯¹ß¼º ¾È¸éÈ«Á¶¸¦ °¨¼ÒÇϸ鼭 ³»ÀμºÀ» Áõ°¡½ÃÅ°´Â ¿ä¼Ò



1. ȯÀÚ¿¡°Ô ¿ì¼± óÀ½ »ç¿ë ½Ã È«Á¶ ¹ß»ý °¡´É¼ºÀ» ¼³¸íÇÑ´Ù. er(extended-release) niacinÀÌ ir(immediate-release) niacinº¸´Ù È«Á¶ ¹ß»ý ¸é¿¡¼­ ȯÀÚ ¼øÀÀµµ°¡ ÈξÀ ³ô´Ù. È«Á¶´Â µû²ûµû²ûÇÑ ¿­°¨ÀÌ ¸Ó¸®, ¸ñ ¹× ¾î±ú¿¡ ÁýÁßÇÏ¿© ³ªÅ¸³­´Ù.



ir niacin º¹¿ë 15~30ºÐÈÄ, er niacin º¹¿ë 30¡­120ºÐ ÈÄ¿¡ À¯¹ßµÇ¸ç ¼­¹æÇüÁ¦Á¦ º¹¿ë ÈÄ¿¡´Â »ó´çÈ÷ ´Ù¾çÇÏ°Ô ³ªÅ¸³­´Ù. È«Á¶Çö»óÀº 5~60ºÐÁ¤µµ Áö¼ÓµÈ´Ù. ir niacin Àº Àå½Ã°£ ÀÛ¿ëÁ¦Á¦º¸´Ù ª°Ô ³ªÅ¸³­´Ù.



2. È«Á¶´Â ¾Ë·¯Áö ¹ÝÀÀÀÌ ¾Æ´Ï°í ÇǺο¡¸¸ ±¹ÇѵǸç, ºñ·Ï ºÒÆíÀº ÇÏÁö¸¸ Àå±âÀûÀ¸·Î ÇØ°¡ µÇ´Â °ÍÀº ¾Æ´Ï´Ù. ȯÀÚ°¡ ºñ·Ï ¹Ýº¹ÀûÀÌÁö¸¸ ªÀº ±â°£ ÇǺÎÀÇ ºÒÄè°¨Àº Á¾Á¾ ÂüÀ» ¼ö ÀÖ´Ù.



ȯÀÚ°¡ Ä¡·á ½Ã ¼ö¹Ý ¹× ¿¹°ßµÇ´Â ºÎÀÛ¿ëÀ¸·Î ºñ·Ï ºÒÆíÇÏÁö¸¸ ½É°¢ÇÑ ¾Ë·¯Áö Çö»óÀÌ ¾Æ´Ï¶ó´Â °ÍÀ» ÀÌÇØÇϸé, ȯÀÚ´Â ºñ·Ï ¹Ýº¹ÀûÀÌÁö¸¸ ªÀº ±â°£ ¹Ì¾àÇÑ ÇǺÎÀÇ ºÒÄè°¨Àº °ßµô ¼ö ÀÖ´Ù. ¼³»ç´Â ÀÏȸ¿ë·®ÀÌ 2,000 mg ÀÌ»óÀÎ niacin¿¡¼­ ¿¹°ßµÇÁö¸¸, ÀÓ»óÀûÀ¸·Î ÃßõÇÏ´Â ¿ë·®Àº ¾Æ´Ï´Ù.



3. niacin Ä¡·á´Â Àú¿ë·®ºÎÅÍ(¿¹ 125~250mg ÇÏ·ç 2ȸ ¶Ç´Â er niacin 500mg ÀáÀÚ±â Àü º¹¿ë) ¼öÁÖ~¼ö°³¿ù¿¡ °ÉÃÄ Á¡Â÷ÀûÀ¸·Î Áõ·®ÇÑ´Ù. È«Á¶´Â niacin 250~1,000mg ¹üÀ§¿¡¼­ ¹ß»ýÇÑ´Ù.



4. È«Á¶ÀÇ ¹ß»ý ºóµµ¿Í Á¤µµ´Â niacin º¹¿ë 30~60 ºÐÀü¿¡ aspirin 325mg, ibuprofen 200mg, ¶Ç´Â ´Ù¸¥ nsaid¸¦ º¹¿ëÇÏ¸é °³¼±µÈ´Ù.



aspirin 81mgÀ¸·Î È«Á¶¸¦ ¿¹¹æÇϱ⿡´Â prostaglandin ÇÕ¼º¾ïÁ¦°¡ ÃæºÐÇÏÁö ¾Ê´Ù. Àå±â»ç¿ë ½Ã niacinÀ» ÇÏ·ç¿¡ ¿©·¯ ¹ø º¹¿ë ½Ã aspirin ¶Ç´Â nsaid Àüóġ´Â ÇÏ·ç¿¡ 1~2ȸ Á¤µµ¸é ÃæºÐÇÏ´Ù. È«Á¶ºóµµ´Â ¼öÁÖ~¼ö°³¿ù¿¡ °ÉÃÄ ¼Ò½ÇµÇ¹Ç·Î ȯÀÚ´Â Æí¸®¼ºÀ» À§ÇÏ¿© aspirin°ú niacin¸¦ º´¿ëÇØ º¹¿ë ÇÒ ¼ö ÀÖ´Ù.



5. Åë»óÀÇ ir niacinÀº ¾Æħ°ú Àú³á½Ä»ç ½Ã, µÎ ¹ø º¹¿ëÇÏ¸ç ½ÄÀü ½ÄÈĺ¸´Ù ½Ä»çÁß°£¿¡ º¹¿ëÇÏ´Â °ÍÀÌ È«Á¶¸¦ °¨¼Ò½ÃÅ°´Â ¹æ¹ýÀÌ´Ù. ¼­¹æÇü niacinÀº ½Ä»ç¿Í °°ÀÌ ÇÏ·ç¿¡ µÎ ¹ø º¹¿ëÇÑ´Ù.



6. ¡®no-flush¡¯ ¶Ç´Â ¡®flush-free¡¯ niacinÀ¸·Î ÆǸŵǴ inositol hexanicotinate´Â À¯¸®Çü niacinÀ» ºÐºñÇϰųª ¼øȯ niacin ³óµµ¸¦ Áõ°¡½ÃÅ°°Å³ª Ç÷Áß ÁöÁú¼öÄ¡¸¦ °³¼±½ÃÅ°Áö ¾Ê°í, »ý¹°ÇÐÀûÀ¸·Î ÀÌ¿ëÇÒ ¼ö ¾øÀ¸¹Ç·Î »ç¿ëÇÏÁö ¾Ê´Â´Ù.



7. er niacinÀ» ÀáÀß ¶§ º¹¿ëÇÏ´Â °ÍÀÌ È«Á¶¸¦ ÃÖ¼ÒÈ­ÇÑ´Ù. ¶Ç´Â ¼Ò·®ÀÇ ÀúÁö¹æ Åë¹Ð Å©·¡Ä¿³ª Áö¹æÁ¦°Å ¿ìÀ¯¿Í º¹¿ë ½Ã È«Á¶¸¦ °¨¼Ò½Ãų ¼ö ÀÖ´Ù.



8. È«Á¶´Â niacinÀÇ ¸ðµç ¿ë·®¿¡¼­ À¯¹ßµÇÁö ¾Ê´Â´Ù. Àӻ󿬱¸¿¡¼­ er niacin ½ÃÀÛ Ã¹ 8ÁÖ°£ Æò±Õ 5ȸ Á¤µµ È«Á¶°¡ ³ªÅ¸³­´Ù.



9. È«Á¶ ºóµµ´Â ¹Ýº¹ÀûÀ¸·Î ÀÏÁ¤ ¿ë·®À» º¹¿ë ½Ã °¨¼ÒÇÑ´Ù. er niacin »ç¿ë 4ÁÖ±îÁö È«Á¶ºóµµ´Â °¨¼ÒÇϱ⠽ÃÀÛÇÑ´Ù.



10. È«Á¶¹ßÇöÀÇ ºóµµ°¡ °¨¼ÒÇÏÁö ¾Ê°Å³ª Àç¹ßÇϸé ÀÏÁ¤ÇÏÁö ¾ÊÀº ¿ë·®¿¡ ±âÀÎÇÑ´Ù. 3ÀÏ ÀÌ»ó niacinº¹¿ëÀÌ ¾ø´Â °æ¿ì´Â ½ÇÁ¦·Î ³ªÅ¸³ª´Â È«Á¶¹ßÇöÀ» ÇÇÇϱâ À§ÇÏ¿© ¿ë·® ÀçÁ¶ÀýÀ» ÇÑ´Ù.



11. niacinÀº Æó°æ±â ½Ã À¯¹ßµÇ´Â È«Á¶¿Í ´Þ¶ó ¶¡Àº µ¿¹ÝÇÏÁö ¾Ê´Â´Ù.



12. ¾ËÄÚ¿Ã, ¸Å¿î À½½Ä, ¶ß°Å¿î À½·á³ª ¶ß°Å¿î ¸ñ¿å µîÀº È«Á¶¸¦ ¾ÇÈ­½ÃÅ°¸ç, niacin º¹¿ë ÀüÈÄ ÃæºÐÇÑ ½Ã°£À» Á¶ÀýÇÑ´Ù.



13. ÀϺΠÀü¹®°¡´Â ÀÔ¿¡¼­ Èí¼öÇÏ´Â, ¾Ã´Â aspirinÀ¸·Î °£È¤ ¿À·¡ Áö¼ÓÇϰųª ½ÉÇÑ È«Á¶ÀÇ ±â°£À» ´ÜÃà½Ãų ¼ö ÀÖ´Ù°í Á¦¾ÈÇÑ´Ù.



niacin ¾ÈÀü¼º¿¡ °üÇÑ Áø·á±ÇÀ¯



1. ȯÀÚÀÇ 5~10%´Â È«Á¶·Î ÀÎÇÏ¿© niacinÀ» Àå±â°£ º¹¿ëÇϱ⠾î·Æ´Ù´Â °ÍÀ» ¿¹°ßÇÒ ¼ö ÀÖ´Ù. ȯÀÚ¿¡°Ô ÃÖ¼±ÀÇ ±³À°¹ýÀ» µ¿¿øÇÏÁö ¾Ê°í ÀϹÝÀûÀÎ Áø·áÇàÅ·δ 90% ÀÌ»óÀÇ Ä¡·á ¼øÀÀ·üÀ» ´Þ¼ºÇϱâ´Â ¾î·Æ´Ù.



2. niacin º¹¿ë¿¡ ÀÇÇÑ ÇǺΠȫÁ¶´Â ¾Ë·¯Áö¿¡ ±âÀÎÇÑ °ÍÀº ¾Æ´ÏÁö¸¸ ÁøÇÇ ³» prostaglandinÀ¯¸®¿Í ÇǺΰÇÁ¶¿¡ ±âÀÎÇÑ´Ù. È«Á¶´Â ÀϺΠº¸½ÀÅ©¸²À̳ª steroid ¿¬°í¿¡ ¹ÝÀÀÀ» ÇÑ´Ù.



±×·¯³ª ´ë°³ niacin°¨·®À̳ª »ç¿ë ÁßÁö°¡ ÇÊ¿äÇÏ´Ù. ½ÀÁøÀÌ ¾ÇÈ­ µÉ ¼ö ÀÖÁö¸¸, °Ç¼±À̳ª ´Ù¸¥ ÇǺκ´º¯ÀÌ niacin¿¡ ¿µÇâÀ» ¹ÞÁö´Â ¾Ê´Â´Ù.



3. ½ÉÇÑ °£µ¶¼ºÀÌ niacinÄ¡·á ½Ã À¯¹ß µÉ ¼öµµ ÀÖÁö¸¸, °ÅÀÇ ¸ðµç °æ¿ì ¼­¹æÇüÁ¦Àç (slow-release formulations sr niacin)¿¡ ±âÀÎÇÑ´Ù. sr niacinº¸´Ù ir(regular or crystalline) niacinÀ̳ª er niacinÀÌ ÀÓ»ó¿¡¼­ ÁÖ·Î »ç¿ëÇÑ´Ù.



±×·¯³ª sr niacin 1,000mg ÀÏÀÏ 2ȸ ¿ë¹ýÀ¸·Î ÁÖ±âÀûÀÎ °£ ±â´É °Ë»ç¿Í º´ÇàÇÏ¿© ȯÀÚ°¡ Àß °ßµð´Â °æ¿ì¿Í ¾çÁúÀÇ Á¦Ç°À» »ç¿ëÇÏ´Â °æÇèÀÌ Àִ Ŭ¸®´Ð °æ¿ì¿¡ ÇÑÇÏ¿© »ç¿ë ÇÒ ¼ö ÀÖ´Ù.



ȯÀÚ°¡ statin°ú sr niacin°ú º´¿ë ½Ã ºñ·Ï °æÁõÀÇ °£µ¶¼ºÀÌ¶óµµ statinÀÇ °£ ´ë»ç¸¦ ÀúÇØÇÏ¿© ½É°¢ÇÑ ±ÙÀ°º´ÁõÀ» À¯¹ßÇÒ ¼ö ÀÖ´Ù.



±×·¯¹Ç·Î statinÀ» º¹¿ëÁßÀΠȯÀÚ¿¡°Ô sr niacinÀº ÀÏÀÏ 1,500mg ÃÑ·®À» ÃÊ°úÇÏ¿©¼­´Â ¾È µÈ´Ù.



4. °£ transaminase °Ë»ç´Â niacin Ä¡·á ù 6~12°³¿ù¿¡¼­´Â ¸Å 6~12ÁÖ¸¶´Ù °Ë»ç¸¦ ÇÏ°í, ÀÌÈÄ ¾à 6~12°³¿ù¸¶´Ù ÁÖ±âÀûÀÎ ÃßÀû°Ë»ç°¡ ÇÊ¿äÇÏ´Ù. Áö¼ÓÀûÀ¸·Î transaminase°¡ 3¹è ÀÌ»ó Áõ°¡Çϰųª, bilirubin ¶Ç´Â prothrombin time ¼öÄ¡º¯È­°¡ µ¿¹ÝÇϰųª ¿À½É, ±¸Åä, ¹ß¿­ÀÌ ÀÖÀ¸¸é niacinÄ¡·á¸¦ ÁßÁöÇϰųª °¨·®ÇÑ´Ù.



5. Ç÷û bilirubin ¼öÄ¡°¡ 3mg/dl ¹Ì¸¸À¸·Î¸¸ ´Üµ¶ Áõ°¡Çϸ鼭 ´Ù¸¥ °£µ¶¼º ¼Ò°ßÀÌ ¾ø´Â °æ¿ì´Â Ưº°È÷ bilirubin À̵¿ÀÇ niacin °£¼·Çö»óÀ̹ǷΠniacin °¨·®À̳ª Áß´ÜÀº ÇÊ¿ä ¾ø´Ù.



6. °æµµÀÇ °£ transaminase Áõ°¡¿Í ¼³¸íµÇÁö ¾Ê´Â prothrombin time Áõ°¡°¡ niacin ºÎÀÛ¿ëÀÎ °æ¿ì´Â µå¹°´Ù. Ç×ÀÀ°íÁ¦ÀÎ warfarin°úÀÇ ¾àÁ¦ »óÈ£ÀÛ¿ëÀÌ ¾øÀ¸¹Ç·Î niacinÀº ¾ÈÀüÇÏ°Ô »ç¿ëÇÑ´Ù.



7. niacinÀº ´ç´¢È¯ÀÚÀÇ ÀÌ»óÁöÁú(ƯÈ÷ Àú hdl ÄÝ·¹½ºÅ×·ÑÇ÷Áõ) Ä¡·á¿¡µµ À¯¿ëÇÏ°Ô »ç¿ëÇÑ´Ù. niacin-À¯Àμº Àν¶¸° ÀúÇ×¼ºÀ¸·Î ¼Ò·®ÀÇ Ç÷´ç ¼öÄ¡´Â Áõ°¡(Æò±Õ 4~5%)ÇÏÁö¸¸, ÀÓ»óÀûÀÎ Á߿伺Àº ¾øÀ¸¸ç, Ç÷´çÀº ½±°Ô Á¶ÀýµÈ´Ù.



´ç´¢È¯ÀÚ¿¡¼­ niacin Ä¡·á½ÃÀÛ°ú ¿ë·®Á¶Àý½Ã Ç÷´çÁ¶ÀýÀº ¹Ýµå½Ã È®ÀÎÇÏ¿©¾ß ÇÑ´Ù.



8. niacinÀ» º¹¿ëÁßÀΠȯÀÚ¿¡¼­ Á¦2Çü ´ç´¢°¡ (¹Ýº¹ÀûÀÎ °øº¹ ½Ã Ç÷´ç¼öÄ¡>125mg/dl ¶Ç´Â ½ÄÈÄ Ç÷´ç¼öÄ¡>200mg/dl) ¹ß»ýÇϸé niacin º¹¿ëÀ» Áß´ÜÇϰųª ¿ë·®À» °¨¼ÒÇÑ´Ù.



niacin-°ü·Ã Àν¶¸° ÀúÇ×¼ºÀº °¡¿ªÀûÀÌ´Ù. ¸¸¾à niacin Áß´Ü ÀÌÈÄ¿¡µµ ´ç´¢°¡ Áö¼ÓµÇ°Å³ª Ä¡·á°¡ ÇÊ¿äÇϸé niacin Àç»ç¿ëÀ» °í·ÁÇϸç, Àç»ç¿ë ½Ã ´ç´¢Ä¡·áÁ¦´Â ¾à°£ÀÇ º¯È­°¡ ÇÊ¿äÇÏ´Ù.



9. niacin-statin º´¿ëÄ¡·á Áß ±ÙÀ°Áõ(myopathic ¹ÝÀÀ ¶Ç´Â ÀÓ»óÀûÀ¸·Î ÀÇÀÇÀÖ´Â myalgia statin ¿ë·®¿¡ Á¦ÇÑÀ» ÁÙ Á¤µµ)ÀÌ À¯¹ßÇϸé, ±ÙÀ°ÁõÀ» À¯¹ßÇÒ ¼ö ÀÖ´Â ´Ù¸¥ º´Áõ Áï, °©»ó¼± ±â´ÉÀúÇÏÁõ, ¾ËÄÚ¿Ã °ú´Ù¼·Ãë, °ú´ÙÇÑ À°Ã¼È°µ¿, °¨¿°, ´Ù¹ß¼º ±Ù¿°, ÁøÇDZÙÀ°¿°Áõ, ¿Ü»ó, ¾à¹°³²¿ë(cocaine, amphetamines, heroin, or pcp) µîµµ °í·ÁÇÑ´Ù.



10. ³¶Á¾ÀÇ È²¹ÝºÎÁ¾À̳ª ´Ù¸¥ ¾È±¸¿µÇâ¿¡ ÀÇÇÑ ½Ã·ÂÀúÇÏ´Â niacin¿ë·®-ÀÇÁ¸¼º ºÎÀÛ¿ëÀ̸ç, niacin Áß´ÜÀ̳ª °¨·®ÀÌ ÇÊ¿äÇÏ´Ù. ´ë°³ niacin <3,000mg/ÀÏ¿¡¼­´Â µå¹°°Ô ³ªÅ¸³­´Ù.



11. niacinÀº È°µ¿¼º À§±Ë¾çÀÌ ÀÖ´Â °æ¿ì »ç¿ëÇÏÁö ¾ÊÁö¸¸, Ä¡À¯µÈ °æ¿ì ±Ý±â´Â ¾Æ´Ï´Ù. À§½Äµµ ¿ª·ù´Â niacin¿¡ ¿µÇâÀ» ¹ÞÁö ¾Ê´Â´Ù.



12. ¿À½É°ú ±¸Åä´Â °í·®ÀÇ niacin¿¡ µ¿¹ÝÇϸç 2,000 mg/ÀϱîÁö´Â µå¹® Çö»óÀÌ´Ù.



13. ½É°èÇ×Áø°ú ºó¸Æµµ niacinÀÇ ºÎÀÛ¿ëÀÌ´Ù. °í¿ë·® ir niacin (2~3g/ÀÏ) »ç¿ëÀÇ Àӻ󿬱¸¿¡¼­ µå¹°°Ô ½É¹æ¼¼µ¿ÀÇ ¹ß»ý°ú °ü·ÃÀÌ ÀÖ´Ù. ±×·¯³ª ½É¹æ¼¼µ¿È¯ÀÚ¿¡¼­ niacinº¹¿ëÀº ±Ý±â°¡ ¾Æ´Ï¸ç, ÀÌ´Â ½É½Ç¹ÝÀÀ Ƚ¼ö¿¡ ¿µÇâÀ» ¹ÌÄ¡Áö ¾Ê±â ¶§¹®ÀÌ´Ù.



14. È°µ¿¼º ÅëdzÀº niacin»ç¿ëÀÇ »ó´ëÀû ±Ý±âÀÌ´Ù. niacinÀº ¼¼´¢°ü¿¡¼­ ´¢»ê ¹è¼³¿¡ °æÀïÀ» ÇϹǷΠÇ÷û ´¢»ê ³óµµ¸¦ 5~15% Áõ°¡½ÃŲ´Ù.



15. °Ë»ç½Ç ¼Ò°ß »ó niacinÀº Ç÷¼ÒÆÇ ¼öÄ¡°¨¼Ò(Æò±Õ11% er niacin 2,000mg)¿Í Ç÷û ³» ÀÎÀ»



°¨¼Ò (Æò±Õ10% er niacin 2,000mg)½ÃŲ´Ù. ¡á



 

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